People with celiac disease will soon be able to prevent the consumption of a large amount of gluten – the substance that causes their symptoms – to get the diagnosis.
New clinical research published in the journal Gastric science Blood tests have shown a “changing game” for Gluten-specific T cells that can detect celiac disease-even if any gluten is taken.
Currently, people suspected of celiac are required to eat a large amount of gluten for weeks to accurately diagnose.
However, the researchers said the new blood test could increase the diagnosis, identify patients at the risk of severe reaction to gluten and diagnose quiet celiac disease in asymptomatic individuals.
Celiac is an autoimmune disease that attacks its tissues when eating gluten, preventing natural digestion and absorption of nutrients and has a risk of serious health complications. By eating gluten, the protein found in wheat, barley and rye is directed.
It is estimated that 1 out of 100 people have it in the UK. However, according to Celiac UK, only 36 % are clinically diagnosed with the disease.
Unexpected or untreated celiac celiac says, it can lead to complications such as osteoporosis, incomprehensible infertility, neurological dysfunction, and in rare cases of small colon cancer.
The researchers said that at present, all Celiac testing methods require regular gluten consumption.
Australia -based scientists added: Many people are prevented from searching for definitive diagnosis because they do not want to consume gluten and become ill.
“There are probably millions of people around the world who live with unnecessary celiac disease because the diagnosis is difficult and sometimes disabled,” said Jason Tayn, head of the Wehi Celiac Research Laboratory and a gastroenterologist at Royal Melbourne Hospital.
“By eliminating the need for a gluten challenge, we deal with one of the biggest deterrents in current diagnostic methods,” he said.
“The experiment can be a game change and destroy thousands and save the emotional and physical emotional return to gluten. This is a big step to diagnose faster and safer.”
The study evaluated the potential of blood tests to measure an IL-2 (IL-2) immune indicator.
In 2019, the researchers found that the immunity in the bloodstream of people with celiac disease was shortly after eating gluten.
Scientists used 181 volunteers using blood samples, including 75 people with celiac disease, 13 people with active, untreated, 32 non -Saadi gluten and 61 healthy individuals.
The participant’s blood sample was then mixed with gluten in a test tube for one day to see if the IL-2 signal appeared.
The “excited” team can detect the conditions with 90 % and 97 % of the characteristics-even in patients following a gluten-free diet, a doctorate researcher, Olivia Meskatley, who had celiac disease at the age of 18.
The IL-2 signal has only increased in volunteers with celiac disease, indicating that the immune response to gluten can be diagnosed without the need for gluten in a tube.
Mscatelli said the experiment also performed great in people with celiac disease, such as type 1 diabetes or Hashimoto’s thyroiditis.
The Walter and Eliza Hall Institute team is now working with Novia drugs to confirm the test in a variety of populations and find real -world data.
